Please see Google Scholar for the most up-to-date publication list.
Education
Harvard University, Cambridge, MA
Ph.D. in Organismic and Evolutionary Biology, May 2013
Dissertation: Dynamics of infection, mutation, and eradication in HIV and other evolving populations
Advisor: Martin A. Nowak
Harvard University, Cambridge, MA
A.B. cum laude with honors in Mathematics & Philosophy, 2005
Research Experience Postdoctoral Research Scientist, Feb. 2014 - present Advisor: Raul Rabadan Harvard University Program for Evolutionary Dynamics, Cambridge, MA Johns Hopkins University School of Medicine, Baltimore, MD (joint affiliation) Postdoctoral Fellow, June 2013 - Jan. 2014 Advisors: Martin A. Nowak (Harvard), Robert F. Siliciano (Hopkins) Johns Hopkins University School of Medicine, Baltimore, MD Laboratory Trainee (BSL-3) and Visiting Student, Jan. 2011 - May 2013 Advisor: Robert F. Siliciano Harvard University Program for Evolutionary Dynamics, Cambridge, MA Ph.D. Student, Sept. 2008 - May 2013 Thesis Advisor: Martin A. Nowak Research and Teaching Interests
Mathematical biology for medicine & public health: virus evolution, drug resistance, epidemiology HIV treatment, adherence, and latent reservoir dynamics Computational and topological methods in human and viral genomics Evolutionary dynamics, bioinformatics, statistics, and population genetics Modeling mutation rates and recombination rates, hypermutation and recombination hotspots Cultural evolution and imitation dynamics Fellowships, Grants, and Awards
Gates Foundation Grand Challenges Explorations Grant, 2012 - 2013
Funding to develop a gene therapy to eradicate the latent reservoir in HIV infection; co-awardees: Hill AL, Rabi SA, Laird G
Stipend & tuition for three years
For teaching of Mathematical Biology & Evolutionary Dynamics
Teaching and other Education Experience
Columbia University Guest Lecturer, Computational Aspects of Infectious Diseases (two 3-hour talks), Spring 2014 Harvard University
Advised three undergraduate theses in HIV population genetics, HIV treatment, and dynamical systems of viral infections, Fall 2011 - Spring 2013 Course Assistant, Evolutionary Dynamics graduate seminar (22 enrolled), Spring 2012
Course Assistant, Mathematical Biology undergraduate course:
Guest Lecturer, Mathematical Biology (eight 90-minute talks), 2009 - 2012
Xidian University, Xi'an, China
Guest Speaker, hour-long seminar on graduate study in the U.S., October 2009
Harvard-MIT Mathematics Tournament, Cambridge, MA
Director of undergraduate-run math competition for high school students, May 2002 - April 2004
Fresh Pond Enrichment Program, Alewife, MA
First- and Second-grade science enrichment teacher, Fall 2001
Other Professional Experience
Private Hedge Fund
Mathematical Modeler & Analyst, 2008 - 2010
Fair Isaac Co. (NYSE: FICO)
Business Strategy Analyst & Consultant, 2005 - 2008
Peer-Reviewed Publications * Denotes equal author contributions Hill AL*, Rosenbloom DIS*, Fu F, Nowak MA, Siliciano RF (2014, in press). Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. PNAS. Rosenbloom DIS, Allen B (2014). Frequency-dependent selection can lead to evolution of high mutation rates. American Naturalist 183(5): 131 – 153. Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom DIS, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, Barouch DH (2014, in press). Rapid seeding of the viral reservoir prior to SIV viremia in rhesus monkeys. Nature. Ho Y-C, Shan L, Hosmane N, Wang J, Laskey SB, Rosenbloom DIS, Lai J, Blankson JN, Siliciano JD, Siliciano RF (2013). Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155(3): 540 – 551. Rosenbloom DIS*, Hill AL*, Rabi SA*, Siliciano RF, Nowak MA (2012). Antiretroviral dynamics determines HIV evolution and predicts therapy outcome. Nature Medicine 18: 1378 – 1385. Allen B, Rosenbloom DIS (2012). Mutation rate evolution in replicator dynamics. Bulletin of Mathematical Biology 74(11): 2650 – 2675. Hill AL, Rosenbloom DIS, Nowak MA (2012). Evolutionary dynamics of HIV at multiple spatial and temporal scales. Journal of Molecular Medicine 90: 543 – 561. Fu F*, Rosenbloom DI*, Wang L, Nowak MA (2011). Imitation dynamics of vaccination behaviour on social networks. Proceedings of the Royal Society B 278: 42 – 49. Under Revision/Submission Camara PG, Rosenbloom DIS, Emmett KJ, Levine AJ, Rabadan R. Fine-scale resolution of human recombination using topological data analysis. Moreno-Gamez S, Hill AL, Rosenbloom DIS, Petrov DA, Nowak MA, Pennings P. Imperfect drug penetration leads to rapid evolution of multi-drug resistance. Research Tools & Educational Resources Evolutionary dynamics & mathematical biology teaching – online educational resource, featured in the Drexel University Math Forum reboundtimes – program for estimating time to viral rebound after interruption of HIV antiretroviral therapy IUPMStats – program for computing infection frequencies from limiting dilution assays Presentations & Conference Proceedings
International Conference on Machine Learning, Beijing, June 2014. Parametric inference using persistence diagrams: a case study in population genetics. Co-author of conference paper. Univ. of Delaware Series on Bioinformatics & Computational Biology, Newark, DE, March 2014. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Invited speaker. Workshop on Topological Structures in Computational Biology, Inst. for Mathematics and its Applications, Minneapolis, MN, December 2013. Persistent homology estimators of evolutionary history. Poster presentation. XIV Congress of the European Society for Evolutionary Biology, Lisbon, Portugal, August 2013. The role of drug penetration in the evolution of multi-drug resistance. Co-author of published abstract. 8th International Conference on HIV Treatment and Prevention Adherence, Miami, FL, June 2013. Modeling treatment outcomes using rich adherence data & antiretroviral pharmacometrics. Oral presentation. 20th International Workshop on HIV Dynamics & Evolution, Utrecht, Netherlands, May 2013. Predicting outcomes of treatments to eradicate the latent reservoir. Oral presentation. 20th International Workshop on HIV Dynamics & Evolution, Utrecht, Netherlands, May 2013. Discordant drug penetration promotes the evolution of multi-drug resistance. Co-author of published abstract. 20th International Workshop on HIV Dynamics & Evolution, Utrecht, Netherlands, May 2013. Estimating the efficacy of latency reversing agents from residual viremia measurements. Co-author of published abstract. 20th Conference on Retroviruses and Opportunistic Infections (CROI), Atlanta, GA, March 2013. Predicting outcomes of treatments to eradicate the HIV latent reservoir. Co-author of published abstract. 19th International Workshop on HIV Dynamics & Evolution, Asheville, NC, April 2012. Antiretroviral dynamics determines HIV evolution and predicts therapy outcome. Oral presentation. Harvard University Organismic & Evolutionary Biology Department Seminar, Cambridge, MA October 2012. Dynamics of HIV treatment, resistance, and the latent reservoir. Oral presentation. Harvard University Microbial Evolution Seminar, Cambridge, MA June 2011. Predicting HIV treatment success, failure, and drug resistance. Oral presentation. Harvard University Organismic & Evolutionary Biology Department Retreat, Petersham, MA, February 2011. Modeling HIV evolution and drug resistance. Oral presentation. Harvard University Organismic & Evolutionary Biology Department Retreat, Petersham, MA, February 2010. Games and the evolution of high mutation rates. Oral presentation. Conference on Evolutionary Dynamics, Peking University, Beijing, October 2009. Imitation dynamics of vaccination. Invited speaker. Santa Fe Institute Complex Systems Summer School, Beijing, August 2005. Nonsyntactic human communication. Oral presentation of working paper. Reviewer for
PLoS Computational Biology PLoS ONE
Journal of Theoretical Biology
IEEE Transactions on Biomedical Engineering
Poznan Studies in Contemporary Linguistics
Journal of Applied Mathematics
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