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Daniel Ian Scholes Rosenbloom

dan...@gmail.com
ICRC Bldg. 8th Floor
1130 St. Nicholas Ave.
New York, NY 10032



Education

Harvard University, Cambridge, MA
Ph.D. in Organismic and Evolutionary Biology, May 2013
Dissertation: Dynamics of infection, mutation, and eradication in HIV and other evolving populations
Advisor: Martin A. Nowak

Harvard University, Cambridge, MA
A.B. cum laude with honors in Mathematics & Philosophy, 2005


Research Experience

Postdoctoral Research Scientist, Feb. 2014 - present
Advisor: Raul Rabadan

Johns Hopkins University School of Medicine, Baltimore, MD (joint affiliation)
Postdoctoral Fellow, June 2013 - Jan. 2014
Advisors: Martin A. Nowak (Harvard), Robert F. Siliciano (Hopkins)

Johns Hopkins University School of Medicine, Baltimore, MD
Laboratory Trainee (BSL-3) and Visiting Student, Jan. 2011 - May 2013
Advisor: Robert F. Siliciano

    Ph.D. Student, Sept. 2008 - May 2013
    Thesis Advisor: Martin A. Nowak

    Undergraduate Researcher, 2002 - 2005
    Advisor: Yaneer Bar-Yam


    Research and Teaching Interests

    Mathematical biology for medicine & public health: virus evolution, drug resistance, epidemiology
    HIV treatment, adherence, and latent reservoir dynamics
    Computational and topological methods in human and viral genomics
    Evolutionary dynamics, bioinformatics, statistics, and population genetics
    Modeling mutation rates and recombination rates, hypermutation and recombination hotspots
    Cultural evolution and imitation dynamics

    Fellowships, Grants, and Awards

    Funding to develop a gene therapy to eradicate the latent reservoir in HIV infection; co-awardees: Hill AL, Rabi SA, Laird G

    Stipend & tuition for three years

    For teaching of Mathematical Biology & Evolutionary Dynamics


    Teaching and other Education Experience

    Columbia University
    Guest Lecturer, Computational Aspects of Infectious Diseases (two 3-hour talks), Spring 2014

    Harvard University
    Advised three undergraduate theses in HIV population genetics, HIV treatment, and dynamical systems of viral infections, Fall 2011 - Spring 2013
    Course Assistant, Evolutionary Dynamics graduate seminar (22 enrolled), Spring 2012
    • Fall 2011: Average rating 4.7 / 5.0 (32 enrolled)
    • Fall 2009: Average rating 4.8 / 5.0 (21 enrolled)
    Guest Lecturer, Mathematical Biology (eight 90-minute talks), 2009 - 2012

    Xidian University, Xi'an, China
    Guest Speaker, hour-long seminar on graduate study in the U.S., October 2009

    Director of undergraduate-run math competition for high school students, May 2002 - April 2004

    Fresh Pond Enrichment Program, Alewife, MA
    First- and Second-grade science enrichment teacher, Fall 2001


    Other Professional Experience

    Private Hedge Fund
    Mathematical Modeler & Analyst, 2008 - 2010
    • Designed algorithm to predict asset price changes, translating owner’s strategies into program specifications
    • Supervised programmers’ implementation of algorithm

    Fair Isaac Co. (NYSE: FICO)
    Business Strategy Analyst & Consultant, 2005 - 2008
    • Implemented randomized controlled trial for measuring profitability of marketing campaigns
    • Designed and delivered training in use of graph-theoretic analytics software to identify “baskets” of products that customers often purchase together
    • Programmed and presented results of customer profitability study, analyzing billions of transactions in Teradata SQL database


    Peer-Reviewed Publications
    * Denotes equal author contributions

    Hill AL*, Rosenbloom DIS*, Fu F, Nowak MA, Siliciano RF (2014, in press). Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. PNAS.

    Rosenbloom DIS, Allen B (2014). Frequency-dependent selection can lead to evolution of high mutation rates. American Naturalist 183(5): 131 – 153.

    Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom DIS, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, Barouch DH (2014, in press). Rapid seeding of the viral reservoir prior to SIV viremia in rhesus monkeys. Nature.

    Ho Y-C, Shan L, Hosmane N, Wang J, Laskey SB, Rosenbloom DIS, Lai J, Blankson JN, Siliciano JD, Siliciano RF (2013). Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155(3): 540 – 551.

    Rosenbloom DIS*, Hill AL*, Rabi SA*, Siliciano RF, Nowak MA (2012). Antiretroviral dynamics determines HIV evolution and predicts therapy outcome. Nature Medicine 18: 1378 – 1385.

    Allen B, Rosenbloom DIS (2012). Mutation rate evolution in replicator dynamics. Bulletin of Mathematical Biology 74(11): 2650 – 2675.

    Hill AL, Rosenbloom DIS, Nowak MA (2012). Evolutionary dynamics of HIV at multiple spatial and temporal scales.  Journal of Molecular Medicine 90: 543 – 561.

    Fu F*, Rosenbloom DI*, Wang L, Nowak MA (2011). Imitation dynamics of vaccination behaviour on social networks.  Proceedings of the Royal Society B 278: 42 – 49.


    Under Revision/Submission

    Camara PG, Rosenbloom DIS, Emmett KJ, Levine AJ, Rabadan R. Fine-scale resolution of human recombination using topological data analysis.

    Moreno-Gamez S, Hill AL, Rosenbloom DIS, Petrov DA, Nowak MA, Pennings P. Imperfect drug penetration leads to rapid evolution of multi-drug resistance.


    Research Tools & Educational Resources

    Evolutionary dynamics & mathematical biology teaching – online educational resource, featured in the Drexel University Math Forum

    reboundtimes – program for estimating time to viral rebound after interruption of HIV antiretroviral therapy

    IUPMStats – program for computing infection frequencies from limiting dilution assays


    Presentations & Conference Proceedings


    Univ. of Delaware Series on Bioinformatics & Computational Biology, Newark, DE, March 2014. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Invited speaker.

    Workshop on Topological Structures in Computational Biology, Inst. for Mathematics and its Applications, Minneapolis, MN, December 2013. Persistent homology estimators of evolutionary history. Poster presentation.

    XIV Congress of the European Society for Evolutionary Biology, Lisbon, Portugal, August 2013. The role of drug penetration in the evolution of multi-drug resistance. Co-author of published abstract.


    20th International Workshop on HIV Dynamics & Evolution, Utrecht, Netherlands, May 2013. Predicting outcomes of treatments to eradicate the latent reservoir. Oral presentation.

    20th International Workshop on HIV Dynamics & Evolution, Utrecht, Netherlands, May 2013. Discordant drug penetration promotes the evolution of multi-drug resistance. Co-author of published abstract.

    20th International Workshop on HIV Dynamics & Evolution, Utrecht, Netherlands, May 2013. Estimating the efficacy of latency reversing agents from residual viremia measurements. Co-author of published abstract.

    20th Conference on Retroviruses and Opportunistic Infections (CROI), Atlanta, GA, March 2013. Predicting outcomes of treatments to eradicate the HIV latent reservoir. Co-author of published abstract.

    19th International Workshop on HIV Dynamics & Evolution, Asheville, NC, April 2012. Antiretroviral dynamics determines HIV evolution and predicts therapy outcome. Oral presentation.

    Harvard University Organismic & Evolutionary Biology Department Seminar, Cambridge, MA October 2012. Dynamics of HIV treatment, resistance, and the latent reservoir. Oral presentation.

    Harvard University Microbial Evolution Seminar, Cambridge, MA June 2011. Predicting HIV treatment success, failure, and drug resistance. Oral presentation.

    Harvard University Organismic & Evolutionary Biology Department Retreat, Petersham, MA, February 2011. Modeling HIV evolution and drug resistance. Oral presentation.

    Harvard University Organismic & Evolutionary Biology Department Retreat, Petersham, MA, February 2010. Games and the evolution of high mutation rates. Oral presentation.

    Conference on Evolutionary Dynamics, Peking University, Beijing, October 2009. Imitation dynamics of vaccination. Invited speaker.

    Santa Fe Institute Complex Systems Summer School, Beijing, August 2005. Nonsyntactic human communication. Oral presentation of working paper.


    Reviewer for
    PLoS Computational Biology
    PLoS ONE
    Journal of Theoretical Biology
    IEEE Transactions on Biomedical Engineering
    Poznan Studies in Contemporary Linguistics
    Journal of Applied Mathematics